Search results for "Adult stem cell pluripotency"

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Donor age and long-term culture do not negatively influence the stem potential of limbal fibroblast-like stem cells

2016

AbstractBackgroundIn regenerative medicine the maintenance of stem cell properties is of crucial importance. Ageing is considered a cause of reduced stemness capability. The limbus is a stem niche of easy access and harbors two stem cell populations: epithelial stem cells and fibroblast-like stem cells. Our aim was to investigate whether donor age and/or long-term culture have any influence on stem cell marker expression and the profiles in the fibroblast-like stem cell population.MethodsFibroblast-like stem cells were isolated and digested from 25 limbus samples of normal human corneo-scleral rings and long-term cultures were obtained. SSEA4 expression and sphere-forming capability were ev…

0301 basic medicineHomeobox protein NANOGCellular differentiationMedicine (miscellaneous)BiologyStem cell markerBiochemistry Genetics and Molecular Biology (miscellaneous)Settore MED/13 - Endocrinologia03 medical and health sciencesAdult stem cell pluripotency; Fibroblast-like stem cells; Limbal stem cells; Proteomic profile; Regenerative medicineLimbal stem cellStem cell transplantation for articular cartilage repairAdult stem cell pluripotencyInduced stem cellsResearchFibroblast-like stem cellProteomic profileCell BiologyCell biologyEndothelial stem cell030104 developmental biologyRegenerative medicineMolecular MedicineLimbal stem cellsStem cellFibroblast-like stem cellsAdult stem cellStem Cell Research & Therapy

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